HRID2410602

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58066291

未命名化合物

结构：CN(CC(=O)OC(C)(C)C)Cc1ccc(C(N)=NO)cc1

HCID76685327

未命名化合物

PRODUCTS

生成物

结构：COCc1cc(-c2nc(-c3ccc(CN(C)CC(=O)OC(C)(C)C)cc3)no2)ccc1-c1ccccc1Cl

HCID66678358

未命名化合物

结构：COCc1cc(-c2nc(-c3ccc(CN(C)CC(=O)O)cc3)no2)ccc1-c1ccccc1Cl.Cl

HCID131731804

未命名化合物

PROCEDURE

实验过程

Tert-butyl N-(4-{5-[2′-chloro-2-(methoxymethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate was prepared following the general procedure 3 starting from Intermediate 13 and Intermediate 31. It was deprotected following the general procedure 8 affording the title compound as a white powder. LC/MS (Method B): 476.2 (M−H)−, 478.1 (M+H)+. HPLC (Method A) Rt 3.95 min (Purity: 99.5%). Melting point: 194-200° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-51c5604cae0949908d329b138e49421e
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08815919B2
来源说明: uspto-grants-2014_08

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][C:9]=1[CH2:17][O:18][CH3:19].[NH2:20][C:21](=[N:39][OH:40])[C:22]1[CH:38]=[CH:37][C:25]([CH2:26][N:27]([CH3:36])[CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:16][N:39]=[C:21]([C:22]3[CH:38]=[CH:37][C:25]([CH2:26][N:27]([CH3:36])[CH2:28][C:29]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:30])=[CH:24][CH:23]=3)[N:20]=2)=[CH:10][C:9]=1[CH2:17][O:18][CH3:19].[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:40][N:39]=[C:21]([C:22]3[CH:23]=[CH:24][C:25]([CH2:26][N:27]([CH3:36])[CH2:28][C:29]([OH:31])=[O:30])=[CH:37][CH:38]=3)[N:20]=2)=[CH:10][C:9]=1[CH2:17][O:18][CH3:19]