2'-Chloro-3'-fluoro-2-(methoxymethyl)biphenyl-4-carboxylic acid → HCID 131731806, compound

Participants

Reaction Steps

Tert-butyl N-(4-{5-[2′-chloro-3′-fluoro-2-(methoxymethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate was prepared following the general procedure 3 starting from Intermediate 62 and Intermediate 31. It was hydrolyzed following general procedure 8 to afford the title compound as a white powder (326 mg, 80%). 1H NMR (DMSO-d6, 300 MHz) δ 8.35 (brs, 1H), 8.22 (m, 3H), 7.81 (d, J=8.4 Hz, 2H), 7.59-7.48 (m, 3H), 7.26 (m, 1H), 4.48 (brs, 2H), 4.28 (m, 2H), 4.11 (brs, 2H), 3.25 (s, 3H), 2.81 (s, 3H). LC/MS (Method B): 496.1 (M+H)+, 494.2 (M−H)−. HPLC (Method A) Rt 3.96 min (Purity: 100%).

Provenance & Evidence