HCID 86628166, compound → HCID 57587122, compound

Participants

Reaction Steps

Hydrogenation is carried out with hydrogen in a Parr reactor. Pd—C 120 mg, 12-amino-N-(benzyloxy)dodecanamide (1.0 g, 2.4 mmol) and ethanol (40 mL) are put into the reactor. It is advisable to heat the product in the ethanol to 50° C. first in an Erlenmeyer flask. Hydrogenation lasts 30 hours, after which filtration is carried out on a porous septum with a layer of celite, washing the septum several times with ethanol. The solution is concentrated in the Rotovapor and in the high vacuum pump to give 12-amino-N-hydroxy dodecanamide as a white solid (500 mg, Yield=66%).

Provenance & Evidence