Methanesulfonyl chloride → n-(4-Methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

HRID 2410632Notes

Reaction equation

HRID 2410632 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[S:15](=[O:18])(=[O:17])[NH2:16])=[O:6].[CH3:20][S:21](Cl)(=[O:23])=[O:22]>N1C=CC=CC=1>[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:10][C:9]=1[S:15](=[O:18])(=[O:17])[NH2:16])=[O:6]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 86762633HCID 86762633, compound2×

Product 1

HCID 24858399n-(4-Methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

mesylating the N-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester (IV), via addition of methanesulfonyl chloride to a suspension of N-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester (IV) and pyridine to form the intermediate compound N-(4-methanesulfonylamino-2-sulfamoyl-phenyl)-malonamic acid methyl ester (V).

Sources & evidence

ORD record
ord-27a945a5572a4940aa4580e9029999e9
Source dataset
uspto-grants-2014_08
Patent number
US08816120B2

Reaction notes

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