Toluene → HCID 66599429, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-2-fluorobenzonitrile (400 mg, 2.000 mmol) and (Ph3P)4Pd (116 mg, 0.100 mmol) were mixed in a microwave tube (20 mL) and flushed with nitrogen. Toluene (5 mL), 2 M aqueous sodium carbonate (2.270 mL, 4.54 mmol) and a solution of 3,4-dichlorophenylboronic acid (519 mg, 2.72 mmol) in MeOH (3 mL) were added. The mixture was heated in an oil bath at 105° C. for 4.5 h. After cooling to room temperature, the reaction was diluted with water (10 mL) and the two phases were separated. The aqueous phase was extracted with ethyl acetate (20 mL), and combined organic phases were washed with water (2×10 mL), 5% aqueous NH4OH (10 mL), and brine (10 mL). The organic phase was dried over Na2SO4 and the solvent was removed. The residue was chromatographed on silica gel eluting with hexane containing 0, 2, 3% ethyl acetate to afford 480 mg of product as a white solid which was about 76% pure by LC/MS. This was used as such in the next step.

Provenance & Evidence