Toluene → HCID 66604864, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-2-(4-(morpholine-4-carbonyl)phenylamino)benzonitrile (300 mg, 0.777 mmol), Pd(Ph3P)4 (44.9 mg, 0.039 mmol), aqueous 2M Na2CO3 (0.882 mL, 1.763 mmol) were mixed with toluene (4 mL) in a sealed microwave tube. 3,4-dimethylphenylboronic acid (163 mg, 1.087 mmol) in MeOH (2.00 mL) was added to the above mixture. The mixture was heated at 105° C. for 4 hrs in an oil bath. The crude was diluted with CH2Cl2 (100 ml) and washed with water (2×50 ml), brine, dried with MgSO4 and concentrated. 378 mg of crude product (77% purity) was obtained and it will be used as it is.

Provenance & Evidence