Acetic Acid → HCID 66599388, compound

Participants

Reaction Conditions

Reaction Steps

A 5 ml microwave vial was loaded with 4-(3-cyano-2′-methoxybiphenyl-4-ylamino)benzoic acid (63 mg, 0.161 mmol), Acetic Acid (4 ml) and Palladium(II) acetate (106 mg, 0.472 mmol), sealed and heated to 130° C. for 12 hours. The reaction mixture was filtered through a 0.45 um Nylon filter, the filter rinsed with acetic acid and the collected liquids evaporated. 31.5 mg of 8-carbamoyl-6-(2-methoxyphenyl)-9H-carbazole-3-carboxylic acid were isolated as a brown film and used without further purification. MS (ESI) m/z 359 (M−H).

Provenance & Evidence