反应详情

A solution of methyl 3-azido-2-(4-(2-methoxyethoxy)phenyl)-6-(4-methoxyphenyl)-isonicotinate (42 mg, 0.097 mmol) in 1,2-dichlorobenzene (2 mL) was heated at 160° C. for 10 min. The solvent was removed under a stream of nitrogen and the residue was purified by radial chromatography (step gradient elution with hexane containing 10 to 50% EtOAc) to give methyl 7-(2-methoxyethoxy)-2-(4-methoxyphenyl)-5H-pyrido[3,2-b]indole-4-carboxylate (28 mg) as a solid. MS (ESI) m/z 407.2 (M+H). 1H NMR (CDCl3) δ ppm 9.38 (1H, s), 8.29 (1H, d, J=8.24 Hz), 8.13 (1H, s), 8.10 (2H, d, J=8.55 Hz), 7.03 (2H, d, J=8.55 Hz), 6.94-7.02 (2H, m), 4.19-4.28 (2H, m), 4.07 (3H, s), 3.88 (3H, s), 3.79-3.84 (2H, m), 3.49 (3H, s).

1. customThe solvent was removed under a stream of nitrogen
2. customthe residue was purified by radial chromatography (step gradient elution with hexane containing 10 to 50% EtOAc)