Ammonium formate → HCID 178488616, compound

Participants

Reaction Steps

A mixture of 7-(benzyloxy)-2-(4-methoxyphenyl)-5H-pyrido[3,2-b]indole-4-carboxamide (Example 206, 155 mg, 0.366 mmol), 10% palladium on activated carbon (75 mg) and ammonium formate (115 mg, 1.83 mmol) was heated at reflux for 2 hr. Filtration followed by removal of the solvent form the filtrate. The residue was suspended in methylene chloride and filtration afforded 7-hydroxy-2-(4-methoxyphenyl)-5H-pyrido[3,2-b]indole-4-carboxamide (109 mg) as a yellow solid. MS (ESI) m/z 334.1 (M+H). 1H NMR (DMSO-d6) δ ppm 11.23 (1H, br. s.), 9.75 (1H, br. s.), 8.52 (1H, br. s.), 8.17-8.26 (3H, m), 8.01 (1H, d, J=8.24 Hz), 7.79 (1H, br. s.), 7.04-7.13 (3H, m), 6.74 (1H, dd, J=8.39, 1.98 Hz), 3.85 (3H, s).

Provenance & Evidence