Methanol → HCID 178499136, compound

Participants

Reaction Steps

Potassium 2,6-dihydroxy-5-nitropyrimidine-4-carboxylate (25 gm, 105 mmol) was dissolved in MeOH (75 mL) and sulphuric acid (21 mL) was added dropwise. The reaction was heated at reflux overnight. After cooling to room temperature, the precipitate was collected by filtration, washed with water, and dried to give methyl 2,6-dihydroxy-5-nitropyrimidine-4-carboxylate (17.1 g) as a white solid. 1H NMR (DMSO-d6) δ ppm 12.04 (2H, br. s.), 3.90 (3H, s).

Provenance & Evidence