Ammonia → 2-(3-chlorophenyl)-7-(4-morpholinyl)-5H-pyrido[2',3':4,5]pyrrolo[2,3-b]pyridine-4-carboxamide

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Reaction Steps

A solution of methyl 2-(3-chlorophenyl)-7-(4-morpholinyl)-5H-pyrido[2′,3′:4,5]pyrrolo[2,3-b]pyridine-4-carboxylate (50 mg, 0.12 mmol) in a solution of 7 N NH3 in MeOH (5 mL) in a sealed microwave vial was heated at 80° C. for 48 hr. Filtration gave 2-(3-chlorophenyl)-7-(4-morpholinyl)-5H-pyrido[2′,3′:4,5]pyrrolo[2,3-b]pyridine-4-carboxamide (10 mg, 0.022 mmol, 19% yield) as a yellow solid. MS (ESI) m/z 408 (M+H). 1H NMR (DMSO-d6) δ ppm 10.97 (s, 1H), 8.53 (br. s., 1H), 8.19-8.44 (m, 4H), 7.88 (br. s., 1H), 7.41-7.63 (m, 2H), 6.87 (br. s., 1H), 3.56-3.88 (m, 8H).

Provenance & Evidence