Potassium Phosphate, Tribasic → HCID 66604320, compound

Participants

Reaction Conditions

Reaction Steps

A microwave vial containing a mixture of methyl 5-(4-methoxybenzyl)-2-(3-(trifluoromethyl)phenyl)-7-(trifluoromethylsulfonyloxy)-5H-pyrido[3,2-b]indole-4-carboxylate (51 mg, 0.08 mmol), cis-2,6-dimethylmorpholine (9.8 μL, 0.080 mmol), powdered potassium phosphate, tribasic (51 mg, 0.240 mmol), biphenyl-2-yldi-tert-butylphosphine (11 mg, 0.036 mmol), and Pd(OAc)2 (2.7 mg, 0.012 mmol) was flushed with nitrogen. DME (160 μL) was added and the vial was sealed and heated at 80° C. for 24 hr. The reaction was then partitioned between EtOAc and water and the organic phase was washed with brine and dried with sodium sulfate. The solvent was removed and the residue was chromatographed (step gradient elution with hexane containing 50 to 100% DCM) to afford methyl 7-((2S,6R)-2,6-dimethylmorpholino)-5-(4-methoxybenzyl)-2-(3-(trifluoromethyl)phenyl)-5H-pyrido[3,2-b]indole-4-carboxylate (27 mg, 0.045 mmol, 56% yield) as a yellow oil. MS (ESI) m/z 604.40 (M+H). 1H NMR (500 MHz, chloroform-d) δ ppm 8.40 (1H, s), 8.28-8.35 (2H, m), 7.88 (1H, s), 7.56-7.65 (2H, m), 7.03 (1H, dd, J=8.70, 1.98 Hz), 6.89 (2H, d, J=8.55 Hz), 6.81 (1H, d, J=1.83 Hz), 6.72-6.77 (2H, m), 5.66 (2H, s), 3.80-3.89 (2H, m), 3.80 (3H, s), 3.72 (3H, s), 3.54-3.62 (2H, m), 2.54 (2H, m), 1.28 (6H, d, J=6.1).

Provenance & Evidence