1-(2-Hydroxyethyl)-4-methylpiperazine → HCID 66606132, compound

HRID 2410773Notes

Reaction equation

HRID 2410773 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:14]=[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:12]=[C:11]([C:21]([NH2:23])=[O:22])[C:7]=3[NH:8][C:9]=2[CH:10]=1.[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32]O)[CH2:27][CH2:26]1>>[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][O:1][C:2]2[CH:3]=[CH:4][C:5]3[C:6]4[N:14]=[C:13]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=5)[CH:12]=[C:11]([C:21]([NH2:23])=[O:22])[C:7]=4[NH:8][C:9]=3[CH:10]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 2311841-(2-Hydroxyethyl)-4-methylpiperazineHCID 178513536HCID 178513536, compound

Product 1

HCID 66606132HCID 66606132, compound

Procedure

This was similarly prepared from 7-hydroxy-2-phenyl-5H-pyrido[3,2-b]indole-4-carboxamide and 2-(4-methylpiperazin-1-yl)ethanol. MS (ESI) m/z 430.1 (M+H). 1H NMR (400 MHz, MeOD) δ ppm 8.20-8.27 (1H, m), 8.12 (1H, s), 8.04-8.09 (2H, m), 7.46-7.53 (2H, m), 7.37-7.42 (1H, m), 7.12-7.16 (1H, m), 6.87-6.94 (1H, m), 4.18-4.27 (2H, m), 2.87 (2H, t, J=5.41 Hz), 2.42-2.77 (6H, m), 2.27 (3H, s).

Sources & evidence

ORD record
ord-1948b5fb257944a997283fc0ee931da2
Source dataset
uspto-grants-2014_08
Patent number
US08815840B2

Reaction notes

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