P-Anisidine → 6-chloro-N-(4-methoxyphenyl)-5-methylpyrimidin-4-amine

HRID 241081Notes

Reaction equation

HRID 241081 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4](O)[C:3]=1[CH3:9].[CH3:10][O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:16][C:15]2[CH:17]=[CH:18][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[C:3]=1[CH3:9]

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 178431783HCID 178431783, compound

Product 1

HCID 637345706-chloro-N-(4-methoxyphenyl)-5-methylpyrimidin-4-amine

Procedure

Synthesized according to the method of reagent preparation 49 using 6-chloro-5-methylpyrimidin-4-ol and 4-methoxyaniline in step 1.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-e82967e8b3664001b671f82ae22bb0fd
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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