Ammonium formate → HCID 66605143, compound

Participants

Reaction Steps

A mixture of 7-(4-benzylpiperazin-1-yl)-2-(3-(trifluoromethyl)phenyl)-5H-pyrido[3,2-b]indole-4-carboxamide (20 mg, 0.038 mmol), 10% Pd on carbon (7 mg) and ammonium formate (12 mg, 0.19 mmol) in MeOH (3 mL) was heated at reflux for 0.5 hr. The reaction was cooled to RT, diluted with DCM and filtered. The solvents were removed to leave 7-(piperazin-1-yl)-2-(3-(trifluoromethyl)phenyl)-5H-pyrido[3,2-b]indole-4-carboxamide (9 mg, 0.02 mmol, 52% yield). MS (ESI) m/z 440.16 (M+H). 1H NMR (500 MHz, DMSO-d6) δ ppm 11.32 (1H, s), 8.53-8.65 (3H, m), 8.41 (1H, s), 8.07 (1H, d, J=8.85 Hz), 7.88 (1H, s), 7.69-7.83 (2H, m), 7.21 (1H, d, J=1.83 Hz), 7.00 (1H, dd, J=8.70, 1.98 Hz), 3.13-3.25 (4H, m), 2.82-3.00 (4H, m).

Provenance & Evidence