HCID 66605911, compound → HCID 66604856, compound

HRID 2410844Notes

Reaction equation

HRID 2410844 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6](CCCl)[N:7]=2)[CH:3]=1.Br[C:15]1[CH:16]=[C:17]([C:34]([NH2:36])=[O:35])[C:18]2[NH:19][C:20]3[CH:21]=[C:22]([N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)[CH:23]=[CH:24][C:25]=3[C:26]=2[N:27]=1>>[O:31]1[CH2:32][CH2:33][N:28]([C:22]2[CH:23]=[CH:24][C:25]3[C:26]4[N:27]=[C:15]([C:2]5[CH:3]=[C:4]6[C:8](=[CH:9][CH:10]=5)[N:7]([CH2:21][CH2:22][N:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[N:6]=[CH:5]6)[CH:16]=[C:17]([C:34]([NH2:36])=[O:35])[C:18]=4[NH:19][C:20]=3[CH:21]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 66605911HCID 66605911, compoundHCID 86663061HCID 86663061, compound

Product 1

HCID 66604856HCID 66604856, compound

Procedure

This was similarly prepared from 5-bromo-2-(2-chloroethyl)-2H-indazole and 2-bromo-7-morpholino-5H-pyrido[3,2-b]indole-4-carboxamide. MS (ESI) m/z 526.24 (M+H). 1H NMR (500 MHz, DMSO-d6) δ ppm 11.20 (1H, s), 8.50-8.61 (3H, m), 8.34 (1H, s), 8.26 (1H, d, J=9.15 Hz), 8.09 (1H, d, J=8.85 Hz), 7.80 (1H, br. s.), 7.73 (1H, d, J=9.16 Hz), 7.22 (1H, s), 7.01 (1H, d, J=8.55 Hz), 4.59 (2H, t, J=6.26 Hz), 3.77-3.87 (4H, m), 3.56-3.61 (4H, m), 3.20-3.27 (4H, m), 2.91 (2H, t, J=6.41 Hz), 2.42-2.48 (4H, m).

Sources & evidence

ORD record
ord-3d71977c487b4acaa40d07ecb16902e1
Source dataset
uspto-grants-2014_08
Patent number
US08815840B2

Reaction notes

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