Ammonia → 7-(morpholinosulfonyl)-2-phenyl-5H-pyrido[3,2-b]indole-4-carboxamide

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 7-(morpholinosulfonyl)-2-phenyl-5H-pyrido[3,2-b]indole-4-carboxylate (106 mg, 0.235 mmol) in 7 N NH3 in MeOH (5 mL) in a sealed microwave vial was heated at 80° C. overnight. After cooling to RT, the precipitate was collected, washed with MeOH, and dried to leave 7-(morpholinosulfonyl)-2-phenyl-5H-pyrido[3,2-b]indole-4-carboxamide (67 mg, 0.15 mmol, 62% yield) as yellow fluffy solid. MS (ESI) m/z 435.1 (M−H). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.03 (1H, s), 8.70 (1H, s), 8.59 (1H, s), 8.52 (1H, d, J=8.06 Hz), 8.33 (2H, d, J=7.30 Hz), 8.21 (1H, d, J=1.01 Hz), 8.00 (1H, s), 7.52-7.64 (3H, m), 7.46 (1H, t, J=7.30 Hz), 3.60-3.69 (4H, m), 2.88-2.97 (4H, m).

Provenance & Evidence