Acetic Acid → HCID 66604445, compound

Participants

Reaction Conditions

Reaction Steps

4-Fluoro-2-(4-(morpholine-4-carbonyl)phenylamino)benzonitrile (100 mg, 0.246 mmol) was mixed with Pd(OAc)2 (138 mg, 0.615 mmol) in AcOH (7 mL) in a sealed microwave tube. The mixture was heated in microwave at 160° C. for 90 mins. The mixture was filtered and washed with 5 ml AcOH. The filtrate was concentrated and purified using preparative HPLC to give 4-fluoro-6-(morpholine-4-carbonyl)-9H-carbazole-1-carboxamide. MS (ESI) m/z 342.13 (M+H). 1H NMR (DMSO-d6) δ ppm 11.87 (s, 1H), 8.19 (s, 1H), 8.11 (s, 1H), 8.03 (dd, 1H, J=8.3, 5.0), 7.83(d, 1H, J=8.6), 7.53 (m, 2H), 7.08(m, 1H), 3.64-3.57 (bm, 8H).

Provenance & Evidence