Potassium Phosphate, Tribasic → HCID 66604777, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-8-(morpholine-4-carbonyl)-5H-pyrido[3,2-b]indole-4-carboxamide (100 mg, 0.248 mmol), phenylboronic acid (60.5 mg, 0.496 mmol), potassium phosphate tribasic (168 mg, 0.794 mmol), 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (23.64 mg, 0.050 mmol) and palladium(II) acetate (5.57 mg, 0.025 mmol) were mixed with THF (4 mL) in a sealed microwave tube. The mixture was heated in microwave at 85° C. for 3 hrs. The mixture was concentrated and purified using preparative HPLC to give titled product. MS (ESI) m/z 401.2 (M+H)+. 1H NMR (DMSO-d6) δ ppm 11.8 (s, 1H), 8.65 (s, 1H), 8.5 (s, 1H), 8.32 (m, 3H), 7.94 (s, 1H), 7.81(d, 1H, J=8.2), 7.60(m, 3H), 7.44 (t, 1H, J=7), 3.7-3.5 (bm, 8H).

Provenance & Evidence