反应详情

温度

135 °C

Ethyl 7-(morpholine-4-carbonyl)-3-phenyl-9H-pyrido[3,4-b]indole-1-carboxylate (15 mg, 0.035 mmol) and 7N NH3/MeOH (1.5 mL, 10.50 mmol) were mixed in a sealed microwave tube and heated in microwave at 135° C. for 3.5 hrs. The mixture was concentrated and purified using preparative HPLC to give titled product. MS (ESI) m/z 401.07 (M+H)+. 1H NMR (DMSO-d6) δ ppm 11.83 (s, 1H), 9.07 (s, 1H), 8.43 (m, 4H), 7.89 (s, 1H), 7.84 (s, 1H), 7.53(t, 2H, J=7.6), 7.42 (t, 1H, J=7.3), 7.32 (dd, 1H, J=7.9, 1.5), 3.67-3.43 (bm, 8H).

1. concentrationThe mixture was concentrated
2. custompurified