Bis(2-chloroethyl) ether → 3-bromo-7-morpholino-9H-carbazole-1-carboxamide

Participants

Reaction Conditions

Reaction Steps

7-Amino-3-bromo-9H-carbazole-1-carboxamide (250 mg, 0.822 mmol), 1-chloro-2-(2-chloroethoxy)ethane (0.387 mL, 3.29 mmol), sodium carbonate (697 mg, 6.58 mmol) were mixed in DMF (4 mL) in a sealed microwave vial. The vial was degassed and filled with N2. The mixture was heated in microwave at 200° C. for 2 hrs. The mixture was purified using preparative HPLC to give titled product. MS (ESI) m/z 374.01 (M+H)+.

Provenance & Evidence