HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2410922Generated: November 1, 2026
Morpholine, 4-[[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]- → 3-(3-chloro-4-(morpholinomethyl)phenyl)-7-(6-morpholinopyridin-3-yl)-9H-carbazole-1-carboxamide
https://huagongshe.com/reaction/2410922
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine, 4-[[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]- | HCID 59392678 | — |
| Reactant | 3-bromo-7-(6-morpholinopyridin-3-yl)-9H-carbazole-1-carboxamide | HCID 66604364 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 3-(3-chloro-4-(morpholinomethyl)phenyl)-7-(6-morpholinopyridin-3-yl)-9H-carbazole-1-carboxamide | HCID 66604016 | — |
Reaction Steps
To the reaction mixture above (482A) was added 4-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine 477B (0.098 g, 0.289 mmol) and additional PdCl2(dppf)-CH2Cl2 adduct (0.020 g, 0.024 mmol). The mixture was heated in microwave at 105° C. for 1 hr. The mixture was filtered and then purified using preparative HPLC to give titled product. MS (ESI) m/z 582.21 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08815840B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-fce276f9ef8c48cc957a803bbd744b38 |
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| Source note | uspto-grants-2014_08 |
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