HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → tert-butyl 4-(8-carbamoyl-6-(4-formyl-3-methylphenyl)-9H-carbazol-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Formyl-3-methylphenylboronic acid | HCID 22341466 | — |
| Reactant | tert-butyl 4-(6-bromo-8-carbamoyl-9H-carbazol-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 66604634 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | tert-butyl 4-(8-carbamoyl-6-(4-formyl-3-methylphenyl)-9H-carbazol-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 86663075 | — |
Reaction Steps
To the reaction mixture above (483A) was added 4-formyl-3-methylphenylboronic acid (103 mg, 0.627 mmol), Pd(Ph3P)4 (11.14 mg, 9.64 μmol) and Na2CO3 (0.482 mL, 0.964 mmol). The mixture was stirred at 105 C for 4 hrs. The mixture was filtered and then purified using preparative HPLC to give titled product. MS (ESI) m/z 508.31 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815840B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-bab0b9135edd4537a14525a9bb06c82b |
| Source note | uspto-grants-2014_08 |