Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

tert-Butyl 4-(8-carbamoyl-6-(3-methyl-4-(morpholinomethyl)phenyl)-9H-carbazol-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate 484 (3 mg, 5.17 μmol) was mixed with TFA (0.2 mL, 2.60 mmol) in 1,2-Dichloroethane (0.4 mL). The mixture was stirred at r.t. for 1 hr. The mixture was concentrated to give the titled product as TFA salt. MS (ESI) m/z 481.07 (M+H)+. 1H NMR (MeOD-d4) δ ppm 8.60 (d, 1H, J=1.8), 8.27 (d, 1H, J=1.8), 8.21 (d, 1H, J=8.2), 7.87 (s, 1H), 7.82 (dd, 1H, J=7.9, 1.5), 7.75 (d, 1H, J=1.3), 7.63 (d, 1H, J=7.9), 7.43 (dd, 1H, J=8.2, 1.5), 6.31 (bs, 1H), 4.51 (s, 2H), 4.1-3.85 (m, 6H), 3.56 (t, 2H, J=6.1), 3.47-3.2 (m, 4H), 2.98 (bs, 2H), 2.63 (s, 3H).

Provenance & Evidence