Bis(2-chloroethyl) ether → HCID 66605475, compound

Participants

Reaction Conditions

Reaction Steps

7-Amino-3-(6-methylpyridin-3-yl)-9H-carbazole-1-carboxamide (134 mg, 0.284 mmol), 1-chloro-2-(2-chloroethoxy)ethane (101 mg, 0.709 mmol) and Na2CO3 (180 mg, 1.703 mmol) were mixed with DMF (4 mL) in a sealed microwave vial. The mixture was heated in microwave at 200° C. for 2 hrs. The mixture was filtered and then purified using preparative HPLC to give titled product. MS (ESI) m/z 387.00 (M+H)+. 1H NMR (DMSO-d6) δ ppm 11.16 (s, 1H), 8.97 (s, 1H), 8.53 (s, 1H), 8.3 (s, 1H), 8.18 (s, 1H), 8.15 (dd, 1H, J=8.0, 2.5), 8.05 (d, 1H, J=8.5), 7.51 (s, 1H), 7.37 (d, 1H, J=8.2), 7.24 (s, 1H), 6.94 (d, 1H, J=8.6), 3.8 (m, 4H), 3.19 (m, 4H), 2.53(s, 3H).

Provenance & Evidence