2-Bromo-5-fluorophenol → 1-Bromo-2-(cyclopropylmethoxy)-4-fluorobenzene

HRID 2410937Notes

Reaction equation

HRID 2410937 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].Br[C:11]1([CH3:14])[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH2:14][CH:11]1[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 27246002-Bromo-5-fluorophenolHCID 148649461-Bromo-1-methylcyclopropane

Product 1

HCID 668669451-Bromo-2-(cyclopropylmethoxy)-4-fluorobenzene

Procedure

Starting from commercially available 2-bromo-5-fluoro-phenol and commercially available bromo-methyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5×10−3 mbar.

Sources & evidence

ORD record
ord-60cf32f8382140f683bc27a3bb9169dd
Source dataset
uspto-grants-2014_08
Patent number
US08816085B2

Reaction notes

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