2-Chloromethyl 2-(trimethylsilyl)ethyl ether → Ethyl 7-[2-(cyclopropylmethoxy)-5-fluorophenyl]-2-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Chloromethyl 2-(trimethylsilyl)ethyl ether	HCID 2724271	—
Reactant	ethyl 7-[2-(cyclopropylmethoxy)-5-fluorophenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate	HCID 67773577	—
Product	Ethyl 7-[2-(cyclopropylmethoxy)-5-fluorophenyl]-2-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-3-carboxylate	HCID 67773302	—

Reaction Steps

Starting from ethyl 7-[2-(cyclopropylmethoxy)-5-fluorophenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate (example D.a3) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is prepared as pale yellow viscous oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816085B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-0f236956b5714769bf375ccbcf46c7e6
Source note	uspto-grants-2014_08