4-Amino-1-Boc-piperidine → tert-Butyl 4-{[(7-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-2-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridin-3-yl)carbonyl]amino}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-Amino-1-Boc-piperidine	HCID 1268291	—
Reactant	HCID 67774709	HCID 67774709	—
Product	tert-Butyl 4-{[(7-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-2-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridin-3-yl)carbonyl]amino}piperidine-1-carboxylate	HCID 67775325	—

Reaction Steps

Starting from 7-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-2-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (example D.c4) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816085B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-82dbc8ed659b4530ac6bc50d6d231606
Source note	uspto-grants-2014_08