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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2410997Generated: November 1, 2026

Acetyl chloride → N-(1-acetylpiperidin-4-yl)-7-[2-(cyclopropylmethoxy)-4-fluorophenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

https://huagongshe.com/reaction/2410997

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetyl chlorideHCID 6367—
Reactant7-[2-(cyclopropylmethoxy)-4-fluorophenyl]-2-methyl-N-(piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide hydrochlorideHCID 67775355—
ProductN-(1-acetylpiperidin-4-yl)-7-[2-(cyclopropylmethoxy)-4-fluorophenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamideHCID 67775276—

Reaction Steps

Starting from 7-[2-(cyclopropylmethoxy)-4-fluorophenyl]-2-methyl-N-(piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide hydrochloride (example D.f4) and commercially available acetyl chloride the title compound is obtained as colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816085B2
Source datasetuspto-grants-2014_08
ORD IDord-1bc16f46c839494a8a608d30a812b901
Source noteuspto-grants-2014_08