3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methoxybenzoic acid

HRID 2411143Notes

Reaction equation

HRID 2411143 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13]

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 602411Methyl 4-amino-3-methoxybenzoate

Product 1

HCID 712525024-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methoxybenzoic acid

Procedure

Using methyl 4-amino-3-methoxybenzoate (1.22 g) and 3-chloropropane-1-sulfonyl chloride (1.1 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (1.05 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-40329f47db9f425e872b9c531200acb0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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