3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acid

HRID 2411154Notes

Reaction equation

HRID 2411154 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([CH3:13])[CH:3]=1.Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:13])[CH:3]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 24721080Ethyl 4-amino-2-methylbenzoate

Product 1

HCID 545952974-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acid

Procedure

Using ethyl 4-amino-2-methylbenzoate (5.3 g) and 3-chloropropane-1-sulfonyl chloride (4.8 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (6.49 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-913c5662c45846468d131d57d392b679
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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