3-Chloropropanesulphonyl chloride → HCID 71252841, compound

HRID 2411156Notes

Reaction equation

HRID 2411156 reaction equation
[NH2:1][C:2]1([C:5]2[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1.Cl[CH2:16][CH2:17][CH2:18][S:19](Cl)(=[O:21])=[O:20]>>[O:20]=[S:19]1(=[O:21])[CH2:18][CH2:17][CH2:16][N:1]1[C:2]1([C:5]2[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 45140209Methyl 4-(1-aminocyclopropyl)benzoate

Product 1

HCID 71252841HCID 71252841, compound

Procedure

Using methyl 4-(1-aminocyclopropyl)benzoate (532 mg) and 3-chloropropane-1-sulfonyl chloride (0.44 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (559 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-517f2a6e66fc4bc7a4d1d0129d62515d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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