3-Chloropropanesulphonyl chloride → HCID 71252256, compound

HRID 2411165Notes

Reaction equation

HRID 2411165 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.Cl[CH2:14][CH2:15][CH2:16][S:17](Cl)(=[O:19])=[O:18]>>[O:18]=[S:17]1(=[O:19])[CH2:16][CH2:15][CH2:14][N:1]1[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 55252884Methyl 6-amino-2-methylpyridine-3-carboxylate

Product 1

HCID 71252256HCID 71252256, compound

Procedure

Using methyl 6-amino-2-methylnicotinate (170 mg) described in Preparation Example 36 and 3-chloropropane-1-sulfonyl chloride (0.25 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (220 mg) was obtained.

Sources & evidence

ORD record
ord-7aba251a9d4e4762a4f8091bea20a3d5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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