Benzoyl chloride → 3-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

HRID 2411180Notes

Reaction equation

HRID 2411180 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[CH2:12][C:11]([CH3:14])([CH3:13])[NH:10][C:9]2=[O:15])=[CH:5][CH:4]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:10]1[C:11]([CH3:14])([CH3:13])[CH2:12][N:8]([CH2:7][C:6]2[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:9]1=[O:15])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 712526731-(4-Methoxybenzyl)-4,4-dimethylimidazolidin-2-one

Product 1

HCID 712524583-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

Procedure

Using 1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one (500 mg) described in Preparation Example 54 and benzoyl chloride (0.28 mL) and by the reaction and treatment in the same manner as in Preparation Example 55, the title compound (500 mg) was obtained.

Sources & evidence

ORD record
ord-053d771d665f4303b5198a9b5b988547
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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