Sodium Bicarbonate → 1-(3,5-Dicyclopropylpyridin-2-yl)piperazine

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Reaction Steps

The intermediate 4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (7.4 g) described in Preparation Example 87 was dissolved in chloroform (54 mL), 4N hydrogen chloride/ethyl acetate (22 mL) was added, and the mixture was stirred at room temperature overnight. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, the mixture was extracted with chloroform, and the solvent was evaporated to give the title compound (4.6 g).

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