HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylboronic acid → 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | 1-Tert-butyloxycarbonyl-4-(3-chloro-5-(trifluoromethyl)pyridin-2-YL)piperazine | HCID 57366416 | — |
| Product | 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride | HCID 67380779 | 94.4% |
Reaction Steps
Using the intermediate 4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (7.3 g) described in Preparation Example 84 and cyclopropylboronic acid (4.2 g) and by the reaction and treatment in the same manner as in Preparation Example 82, the title compound (5.8 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-fef2cc84c9bf4abb949eedb7d5258086 |
| Source note | uspto-grants-2014_08 |