Sodium Bicarbonate → 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine

Participants

Reaction Steps

To 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride obtained by using the intermediate 4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (5.86 g) described in Preparation Example 84 and cyclopropylboronic acid (5 g) and by the reaction and treatment in the same manner as in Preparation Example 82 was added saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated to give the title compound (3.62 g).

Provenance & Evidence