tert-Butyl piperazine-1-carboxylate → HCID 71253188, compound

HRID 2411229Notes

Reaction equation

HRID 2411229 reaction equation
BrC1C=CC(C(OC)=O)=CC=1C.C(N1CCNCC1)(OC(C)(C)C)=O.C(OC([N:33]1[CH2:38][CH2:37][N:36]([C:39]2[CH:44]=[CH:43][C:42]([C:45]([O:47][CH3:48])=[O:46])=[CH:41][C:40]=2[CH3:49])[CH2:35][CH2:34]1)=O)(C)(C)C>>[CH3:49][C:40]1[CH:41]=[C:42]([CH:43]=[CH:44][C:39]=1[N:36]1[CH2:37][CH2:38][NH:33][CH2:34][CH2:35]1)[C:45]([O:47][CH3:48])=[O:46]

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 3294148Methyl 4-bromo-3-methylbenzoateHCID 67048475HCID 67048475, compound

Product 1

HCID 71253188HCID 71253188, compound

Procedure

Using methyl 4-bromo-3-methylbenzoate (5 g) and 1-Boc-piperazine (4.47 g) and by the reaction and treatment in the same manner as in Example 94, the title compound (1.05 g) was obtained via 4-(4-methoxycarbonyl-2-methylphenyl)piperazine-1-carboxylic acid tert-butyl ester.

Workup

  1. customby the reaction and treatment in the same manner as in Example 94

Sources & evidence

ORD record
ord-7119eba2032c48748e55c7b4220d09fb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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