1-(2,4-Xylyl)piperazine → HCID 58484529, compound

Participants

Reaction Steps

4-Bromo-2,6-difluorobenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4 g) were dissolved in a solution of chloroform (50 mL) and methanol (50 mL), 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (6.9 g) was added, and the mixture was stirred at room temperature overnight. The solvent was evaporated from the reaction mixture, ethyl acetate was added, and the insoluble material was collected by filtration. The solvent was evaporated from the obtained filtrate to give the title compound (7 g).

Provenance & Evidence