1-(2,4-Xylyl)piperazine → (4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411241Notes

Reaction equation

HRID 2411241 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.[CH3:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:26]2[CH2:27][CH2:28][N:23]([C:17]3[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:16]=3[CH3:15])[CH2:24][CH2:25]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27610574-Bromo-2-methanesulfonylbenzoic acid

Product 1

HCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneYield 80.4%

Procedure

Using 4-bromo-2-methanesulfonylbenzoic acid (1 g) and 1-(2,4-dimethylphenyl)piperazine (684 mg) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (1.3 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-8d861ea91b2146f4bbfb07b01d48995b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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