1-(2,4-Xylyl)piperazine → HCID 58484755, compound

HRID 2411246Notes

Reaction equation

HRID 2411246 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 2389326-Bromonicotinic acid

Product 1

HCID 58484755HCID 58484755, compoundYield 102.5%

Procedure

Using 6-bromonicotinic acid (2 g) and 1-(2,4-dimethylphenyl)piperazine (1.9 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (3.8 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-a07c5c7d88dc4289ab3c8926c78d6f43
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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