4-Bromo-2-methylbenzoic acid → (4-Bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

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Reaction Steps

1-(3,5-Dimethylpyridin-2-yl)piperazine (3.8 g) described in Preparation Example 79 and 4-bromo-2-methylbenzoic acid (4.3 g) were dissolved in a solution of chloroform (30 mL) and methanol (30 mL), 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (8.8 g) was added, and the mixture was stirred at room temperature overnight. The solvent was evaporated from the reaction mixture, ethyl acetate was added, and the insoluble material was collected by filtration. The solvent was evaporated from the obtained filtrate, and the residue was purified by column chromatography (hexane:ethyl acetate) to give the title compound (7 g).

Provenance & Evidence