4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411254Notes

Reaction equation

HRID 2411254 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH:13]1([C:16]2[C:17]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:18][CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=2)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:29]2[CH2:30][CH2:31][N:26]([C:17]3[C:16]([CH:13]4[CH2:15][CH2:14]4)=[CH:21][C:20]([C:22]([F:25])([F:23])[F:24])=[CH:19][N:18]=3)[CH2:27][CH2:28]2)=[O:7])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 67380779HCID 67380779, compound

Product 1

HCID 58484690(4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanoneYield 85.5%

Procedure

Using 4-bromo-2-fluorobenzoyl chloride (2.5 g) and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride (3.2 g) described in Preparation Example 89 and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (4.2 g) was obtained.

Workup

  1. customdescribed in Preparation Example 89 and by the reaction and treatment in the same manner as in Preparation Example 108

Sources & evidence

ORD record
ord-34f71d01ede8469d96496184b729d57c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…