HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylbenzoic acid → (4-Bromo-2-methylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| Reactant | 1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine | HCID 58484718 | — |
| Product | (4-Bromo-2-methylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484636 | 54% |
Reaction Steps
Using 4-bromo-2-methylbenzoic acid (1.00 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.52 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.04 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-bbf17128901f4f388cb267fcd51c8576 |
| Source note | uspto-grants-2014_08 |