HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-fluorobenzoic acid → (4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-fluorobenzoic acid | HCID 2773341 | — |
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Product | (4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484572 | 67.4% |
Reaction Steps
Using 1-(3,5-dimethylpyridin-2-yl)piperazine (2.87 g) described in Preparation Example 79 and 4-bromo-3-fluorobenzoic acid (3.29 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (3.97 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-285bbb2595d14c049e2fa29cf862d38c |
| Source note | uspto-grants-2014_08 |