HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methanesulfonylbenzoic acid | HCID 2761057 | — |
| Reactant | 1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride | HCID 67381091 | — |
| Product | (4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484821 | 94.1% |
Reaction Steps
Using 4-bromo-2-methanesulfonylbenzoic acid (558 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (508 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Preparation Example 119, the title compound (0.9 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-f0c5dd6c29054098ad35eaf3d14bc755 |
| Source note | uspto-grants-2014_08 |