1-(2,4-Xylyl)piperazine → HCID 58484788, compound

HRID 2411261Notes

Reaction equation

HRID 2411261 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[CH:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[C:4]([CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 995704-Bromo-2-methylbenzoic acid

Product 1

HCID 58484788HCID 58484788, compoundYield 98.8%

Procedure

Using 4-bromo-2-methylbenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4.6 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (8.9 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-a76380e285f34508a02efb4ff11bd69c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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