1-(2,4-Xylyl)piperazine → HCID 58484715, compound

HRID 2411262Notes

Reaction equation

HRID 2411262 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([Cl:11])[CH:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[C:4]([Cl:11])[CH:3]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 1088294-Bromo-2-chlorobenzoic acid

Product 1

HCID 58484715HCID 58484715, compoundYield 105%

Procedure

Using 4-bromo-2-chlorobenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (9 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-acd10a3246bb4792a7a60054e8cbe1f6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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