1-(2,4-Xylyl)piperazine → HCID 58484634, compound

HRID 2411263Notes

Reaction equation

HRID 2411263 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[F:11].[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[CH:4][C:3]=1[F:11]

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27733414-Bromo-3-fluorobenzoic acid

Product 1

HCID 58484634HCID 58484634, compoundYield 85.1%

Procedure

Using 4-bromo-3-fluorobenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (7 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-45e0d86c90b947adbe10e1fc2b5893f2
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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