1-(2,4-Xylyl)piperazine → HCID 71252418, compound

HRID 2411267Notes

Reaction equation

HRID 2411267 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[NH2:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 288755296-Amino-2-methylpyridine-3-carboxylic acid

Product 1

HCID 71252418HCID 71252418, compoundYield 16.9%

Procedure

Using 6-amino-2-methylnicotinic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (657 mg) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (180 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-9fa3c233a3ee4e2384eced989b377e18
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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